Serum GDF9 and BMP15 as potential markers of ovarian function in women with and without polycystic ovary syndrome
Authors' conclusion
Serum GDF9 and BMP15 concentrations somewhat reflect ovarian but not androgenic or metabolic characteristics of PCOS, with increased GDF9 reflecting high AFC as seen in PCOM/PCOS.
Study context
- Population
- Women aged 21–45 years, volunteers and patients with possible polycystic ovary syndrome (PCOS), National University Hospital, Singapore
- Participants
- 381 women
- Exposure
- Polycystic ovarian morphology (PCOM) vs PCOS vs control
- Outcome
- Association of serum GDF9/BMP15 with ovarian, pituitary, oestrogenic, androgenic and metabolic characteristics and with PCOM and PCOS
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Serum GDF9 detectable
- 40%
- Serum BMP15 detectable
- 41%
- Correlation GDF9 with BMP15
- r = 0.08, p = 0.003
- GDF9 positively correlated with ovarian volume
- p = 0.02
- GDF9 positively correlated with antral follicle count (AFC)
- p = 0.004
- GDF9 not correlated with AMH
- p = 0.05
- Relationship between GDF9 and AFC differed between control, PCOM and PCOS
- p = 0.02
Observational data: associations, not effects.
Original publication
Serum GDF9 and BMP15 as potential markers of ovarian function in women with and without polycystic ovary syndrome. Clin Endocrinol (Oxf). Published 18 December 2022. doi:10.
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