The effect of hormone replacement therapy on cognition and mood
Authors' conclusion
Further study, particularly focusing on the more contemporaneous HRT preparations, is warranted before evidence-based conclusions can be drawn.
Study context
- Population
- Perimenopausal and menopausal women
- Exposure
- Hormone replacement therapy (HRT) and cognition and mood
- Outcome
- Cognition and mood
Methodological detailsrandomised and observational studies included
- Randomised and observational studies included
Main finding
As reported in the abstract
- Heterogeneous results; firm conclusions challenging
- 'Critical window': HRT may have a positive impact on cognition when given in the peri-menopausal or early postmenopausal period but may have negative effects on cognition in older postmenopausal women
- Evidence suggests importance of hormonal replacement after surgical menopause, especially when young; duration unclear, at least until natural age of menopause seems reasonable
- Evidence for a positive effect of HRT on mood is more convincing, possibly more efficacious in younger women
- Effect of HRT on anxiety less clear
- Many studies used older regimens no longer routinely used clinically
Observational data: associations, not effects.
Original publication
The effect of hormone replacement therapy on cognition and mood. Clin Endocrinol (Oxf). Published 13 December 2022. doi:10.
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