Association of Insulin-Like Growth Factor-1 With Polycystic Ovarian Syndrome: A Systematic Review and Meta-analysis
Pooled result · Serum IGF-1 levelsResult — go to the resultSMD 0.89 95% CI 0.34–1.45Authors' conclusion
These data suggest that elevated serum IGF-1 levels may not be a major cause of PCOS pathogenesis. Body mass index may be a major determinant of serum IGF-1.
Study context
- Population
- Patients with PCOS and normal controls; studies from PubMed, Embase, Web of Science, Cochrane Library and China National Knowledge Infrastructure (up to July 2022)
- Participants
- 657 patients20 studies
- Comparison
- PCOS vs normal controls
- PCOSn = 362
- Controlsn = 295reference
- Outcome
- Serum IGF-1 levels
Methodological detailsrandom-effects model, subgroup analyses, sensitivity analysis
- Random-effects model
- Subgroup analyses
- Sensitivity analysis
Pooled result
As reported in the abstract
SMD
0.89
95% CI 0.34–1.45
P = 0.002
PCOSvs Controls
SMD 0.89 (95% CI 0.34–1.45); P = 0.002
- Heterogeneity I2
- 89%
Further pooled results
Serum IGF-1 by BMI subgroup
- Elevated IGF-1 associated with normal-weight and overweight PCOS patients; no significant association with obesity
Sensitivity analysis and publication bias
- No individual study significantly affected the pooled result; no publication bias observed
Original publication
Association of Insulin-Like Growth Factor-1 With Polycystic Ovarian Syndrome: A Systematic Review and Meta-analysis. Endocr Pract. Published 11 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →