Time‐Restricted Eating to Improve Metabolic Abnormalities in Polycystic Ovarian Syndrome (TimeMAP)
Authors' conclusion
In a 12-week cross-over feasibility study, TRE was a safe and feasible intervention. Recruitment was challenging and with limited numbers, the TRE group showed a decrease in HbA1c and anthropometric indices compared to the 'ad libitum' group.
Study context
- Population
- Women with polycystic ovarian syndrome (PCOS)11 completed
- Participants
- 15 women
- Comparison
- Time-restricted eating (TRE) vs ad libitum eating
- Primary endpoint
- Feasibility of TRE in PCOS: recruitment, compliance, safety, drop-out rate
Primary result
As reported in the abstract
Feasibility
- Eligible to participate
- 70
- Recruited
- 15
- Completed
- 11
- Drop-outs (commitment/study duration)
- 4 [27%]
- Compliance with TRE, %(SD)
- 94.7(4.5)%
- Keen to continue TRE post-study
- 10 participants
Further findings
| Outcome | P value |
|---|---|
| Metabolic and anthropometric indices (exploratory; not powered)TRE vs Ad libitum · HbA1c decreased with TRE · exploratory analysis | P = 0.04 |
| Metabolic and anthropometric indices (exploratory; not powered)TRE vs Ad libitum · Weight decreased with TRE · exploratory analysis | P = 0.001 |
| Metabolic and anthropometric indices (exploratory; not powered)TRE vs Ad libitum · BMI decreased with TRE · exploratory analysis | P = 0.001 |
| Metabolic and anthropometric indices (exploratory; not powered)TRE vs Ad libitum · Hip circumference decreased with TRE · exploratory analysis | P = 0.05 |
| Metabolic and anthropometric indices (exploratory; not powered)TRE vs Ad libitum · Waist circumference decreased with TRE · exploratory analysis | P = 0.001 |
Safety
- Serious adverse events — TRE
- 0 events
Original publication
Time‐Restricted Eating to Improve Metabolic Abnormalities in Polycystic Ovarian Syndrome (TimeMAP). Clin Endocrinol (Oxf). Published 14 January 2026. doi:10.
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