Reproductive endocrinology

Time-restricted eating for body weight management in women with polycystic ovary syndrome: a randomized controlled trial

Nat MedPublished Randomised controlled trial

Authors' conclusion

Our results show that in women with PCOS, TRE induced greater weight loss than the controls and was comparable to that achieved with daily CR.

Study context

Population
Women with polycystic ovary syndrome (PCOS)
Participants
76 women
Comparison
6-h time-restricted eating (TRE) vs daily calorie restriction (CR) vs no-intervention control
Primary endpoint
Percent change in body weight
Follow-up
6 months
Methodological detailsthree-arm
  • Three-arm

Primary result

As reported in the abstract

TRE vs Control

−4.32 %

95% CI −6.20 to −2.44P < 0.01

CR vs Control

−4.66 %

95% CI −7.13 to −2.19P < 0.01

Between TRE and CR · no difference

0.34 %

95% CI −2.15 to 2.83P = 0.79

Safety

No serious adverse events were reported

Original publication

Time-restricted eating for body weight management in women with polycystic ovary syndrome: a randomized controlled trial. Nat Med. Published 27 March 2026. doi:10.1038/s41591-026-04316-7

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