The effects of time‐restricted eating alone or in combination with probiotic supplementation in comparison with a calorie‐restricted diet on endocrine and metabolic profiles in women with polycystic ovary syndrome: A randomized clinical trial
Authors' conclusion
The eTRE alone or eTRE plus probiotics did not result in significantly greater weight loss or improvements in metabolic, menstrual and gonadal variables compared with the standard three-meal DCR diet.
Study context
- Population
- Obese women with polycystic ovary syndrome (PCOS); mean body weight 81.4 kg, mean age 30 years
- Participants
- 90 women
- Comparison
- 14:10 early time-restricted eating (eTRE) alone or with probiotics vs daily calorie restriction (DCR)
- eTRE + probioticsn = 30
- eTRE + placebon = 30
- DCRn = 30reference
Methodological detailsplacebo-controlled, parallel-arm
- Placebo-controlled
- Parallel-arm
Primary result
As reported in the abstract
Weight loss · week 8
eTRE + probiotics
−2.2
mean · SD 1.6 · kg
eTRE + placebo
−2.9
mean · SD 2.7 · kg
DCR
−2.5
mean · SD 1.7 · kg
Further findings
| Outcome | P value |
|---|---|
| Metabolic, menstrual and gonadal variables · 8 weeksBetween eTRE + probiotics and DCR · no significant difference between eTRE groups and control | P > 0.05 |
| Metabolic, menstrual and gonadal variables · 8 weeksBetween eTRE + placebo and DCR · no significant difference between eTRE groups and control | P > 0.05 |
| Hormonal and cardiometabolic factors: probiotics added to eTRE · 8 weeksBetween eTRE + probiotics and eTRE + placebo · no benefit of combining probiotics with eTRE | P > 0.05 |
Metabolic, menstrual and gonadal variables · 8 weeks
- All three regimes reduced body weight, BMI, vascular risk indicators, hirsutism and acne scores
Original publication
The effects of time‐restricted eating alone or in combination with probiotic supplementation in comparison with a calorie‐restricted diet on endocrine and metabolic profiles in women with polycystic ovary syndrome: A randomized clinical trial. Diabetes Obes Metab. Published 14 August 2024. doi:10.
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