Increased MAP-1 and lectin complement activation capacity in Klinefelter syndrome
Authors' conclusion
Men with KS demonstrate increased lectin complement pathway activation capacity, and increased MAP-1 and MASP1-201 expression.
Study context
- Population
- Men with Klinefelter syndrome and age-matched male controls
- Participants
- 45 vs 45
- Exposure
- Men with klinefelter syndrome (KS) vs male controls
- KSn = 45
- Controlsn = 45reference
- Outcome
- Lectin pathway complement activation capacity
Methodological detailsage-matched controls
- Age-matched controls
Main finding
As reported in the abstract
Lectin pathway activation capacity
P < 0.0001
Observational data: associations, not effects.
Further findings
Serum MAP-1
- Serum MAP-1 levels elevated in KS
MASP1-201 expression (skeletal muscle mRNA)
- MASP1-201 expression increased in KS
Serum C3dg
- Serum C3dg not different between KS and controls
Associations of lectin pathway activation capacity
- Not strongly linked to sex hormone levels; only weak association with body fat
Fibrinolysis
- Lectin pathway contributed to fibrin clot lysis variability in KS
- Fibrinogen-C3dg complex levels similar in KS and controls
Original publication
Increased MAP-1 and lectin complement activation capacity in Klinefelter syndrome. J Clin Endocrinol Metab. Published 24 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →