Reproductive endocrinology

Complementary and Alternative Therapies for Genitourinary Syndrome of Menopause : An Evidence Map

Ann Intern MedPublished Systematic review (evidence map) of randomised controlled trials

Authors' conclusion

There is a large and heterogeneous literature of CAM interventions for GSM. Trials were small, and few were done in North America. Standardized population, intervention, comparator, and outcomes reporting in future RCTs are needed.

Study context

Population
Postmenopausal women with genitourinary syndrome of menopause (GSM); Randomized controlled trials (RCTs) ≥8 weeks with ≥20 participants randomly assigned per group57 trials
Comparison
Complementary and alternative medicine or therapies for GSM
Outcome
Evidence map of CAM trials for GSM
Methodological detailsevidence map approach, narrative summaries, English-language studies only, Data abstracted by 1 reviewer and verified by a second, Ovid MEDLINE, EMBASE and CINAHL searched from inception through 11 December 2023
  • Evidence map approach
  • Narrative summaries
  • English-language studies only
  • Data abstracted by 1 reviewer and verified by a second
  • Ovid MEDLINE, EMBASE and CINAHL searched from inception through 11 December 2023

Pooled result

As reported in the abstract

Trials identified
57
Unique interventions investigated
39
Studies typically small
n < 200
Trials done in Iran
k = 24
Trials done in other parts of Asia
k = 9
Trials of natural products (herbal or botanical supplements and vitamins)
k = 44
Trials of mind and body practices
k = 6
Trials of educational programs
k = 7
Trials reporting sexual symptoms
k = 44
Trials reporting vulvovaginal symptoms
k = 30

Safety

Trials reporting on adverse events
k = 33

Original publication

Complementary and Alternative Therapies for Genitourinary Syndrome of Menopause : An Evidence Map. Ann Intern Med. Published 10 September 2024. doi:10.7326/annals-24-00603

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