Ovarian Insufficiency in Adolescent Females with Transfusion-Dependent β-Thalassemia: Pituitary versus Ovarian Iron Overload
Authors' conclusion
Adolescent females with TDT have decreased ovarian reserve, AFC, and gonadotropins that are correlated with serum ferritin, pituitary iron load, and ovarian volume. Hence, regular ovarian reserve assessment should be implemented as a part of endocrinological follow-up of females with TDT advising procedures to preserve fertility to those who are likely to have ovarian insufficiency.
Study context
- Population
- Adolescent females with transfusion-dependent β-thalassemia; mean age 14.54 ± 2.24 years
- Participants
- 50 vs 50
- Comparison
- Adolescent females with TDT vs age-matched healthy females
- TDTn = 50
- Controlsn = 50reference
- Outcome
- Ovarian reserve and pituitary-gonadal axis function, correlated with pituitary and ovarian volume, pituitary iron load and serum ferritin
Methodological detailsage-matched healthy controls
- Age-matched healthy controls
Main finding
As reported in the abstract
Ovarian insufficiency in TDT
TDT
40%
20 of 50
Observational data: associations, not effects.
Further findings
TDT with vs without ovarian insufficiency
- Significantly higher serum ferritin and pituitary MRI-R2* with ovarian insufficiency
- Pituitary MRI-R2* was the most significant independent variable associated with ovarian insufficiency (multivariate logistic regression)
Original publication
Ovarian Insufficiency in Adolescent Females with Transfusion-Dependent β-Thalassemia: Pituitary versus Ovarian Iron Overload. Horm Res Paediatr. Published 9 September 2024. doi:10.
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