Oral contraceptives (OCs) in combination with metformin versus OCs alone on metabolism in nonobese polycystic ovary syndrome: A meta‐analysis and systematic review of randomized controlled trials
Authors' conclusion
Metformin, via its positive effects on insulin clearance, in combination with OCs, improved glucose metabolism and offered a good treatment alternative in nonobese women with PCOS.
Study context
- Population
- Nonobese reproductive-age women with polycystic ovary syndrome (PCOS); Randomized controlled trials (RCTs) in PubMed, EMBASE, Cochrane Library and clinicaltrials.gov up to 30 April 2022, English-language
- Participants
- 707 women14 RCTs
- Comparison
- OCs + metformin vs OCs alone
- Outcome
- Fasting glucose and fasting insulin
- Follow-up
- Study completion
Pooled result
As reported in the abstract
study completion
OCs + metformin vs OCsMD (95% CI)P value
Fasting glucose
−0.21(−0.31 to −0.12)
P < 0.00001Fasting insulin
−2.54(−4.04 to −1.04)
P = 0.0009Further pooled results
Homoeostasis model assessment of insulin resistance (HOMA-IR), high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, TG · study end
- No statistic difference between OCs + metformin and OCs
Original publication
Oral contraceptives (OCs) in combination with metformin versus OCs alone on metabolism in nonobese polycystic ovary syndrome: A meta‐analysis and systematic review of randomized controlled trials. Clin Endocrinol (Oxf). Published 7 April 2023. doi:10.
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