Effect of sleep restriction on insulin sensitivity and energy metabolism in postmenopausal women: A randomized crossover trial
Authors' conclusion
Four nights of SR reduced insulin sensitivity and fat oxidation in postmenopausal women. These findings underscore the role of insufficient sleep in metabolic dysfunction following menopause. Larger trials investigating how sleep disturbances cause metabolic dysfunction during menopause are needed across all stages of menopause.
Study context
- Population
- Postmenopausal women; analysed: mean (SD) age 59 (4) years, BMI 28.0 (2.6) kg/m²9 analysed
- Participants
- 14 women
- Comparison
- Sleep restriction vs habitual sleep, 4 nights each
- Primary endpoint
- Insulin sensitivity by hyperinsulinemic-euglycemic clamp, defined as the glucose infusion rate (GIR)
- Follow-up
- After 4 nights
Methodological detailseucaloric diet
- Eucaloric diet
Primary result
Low-dose insulin GIR
Reduction
20%
P = 0.01
By group
As reported in the abstract
Further findings
High-dose insulin GIR · lower with SR
reduction 12% · P < 0.001
Accelerometer-determined total time in bed · lower with SR
reduction 38% · P < 0.0001
- Fat oxidation during high-dose insulin infusion · reduced with sleep restriction (SR)
- P < 0.01
Resting energy metabolism
- SR did not alter resting energy metabolism
Original publication
Effect of sleep restriction on insulin sensitivity and energy metabolism in postmenopausal women: A randomized crossover trial. Obesity (Silver Spring). Published 30 March 2023. doi:10.
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