Role of kisspeptin in polycystic ovarian syndrome: A metabolomics study
Authors' conclusion
Kisspeptin could be a potential biomarker for the diagnosis of PCOS and plays an important role in metabolic regulation in individuals with PCOS. In addition, metabolomics provides a promising method for the study of metabolic abnormalities in individuals with PCOS, which might contribute to our understanding of its mechanisms.
Study context
- Population
- Patients with polycystic ovary syndrome (PCOS) and control patients
- Participants
- 50 vs 50
- Comparison
- PCOS vs healthy controls
- PCOSn = 50
- Controln = 50reference
- Outcome
- Relationship between serum kisspeptin levels (ELISA) and abnormal metabolism (HPLC-MS/MS serum metabolomics) in PCOS
Main finding
As reported in the abstract
Serum kisspeptin
- Serum kisspeptin positively correlated with LH, T, FFA, BA and LEP levels
- p < 0.05
Observational data: associations, not effects.
Further findings
Serum metabolites (high-kisspeptin PCOS, low-kisspeptin PCOS, healthy controls)
- Significantly dysregulated metabolites, mainly lipid, amino acid and carbohydrate metabolites
- Palmitic acid and N-formylkynurenine lower in high-kisspeptin PCOS than controls
- Metabolite set enrichment (KEGG): significant difference in amino acid and pyruvate metabolism by kisspeptin concentration in PCOS
Original publication
Role of kisspeptin in polycystic ovarian syndrome: A metabolomics study. Clin Endocrinol (Oxf). Published 26 March 2023. doi:10.
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