Young-onset diabetes in women with Polycystic Ovary Syndrome: A territory-wide retrospective analysis in Hong Kong
Main finding · Incident diabetesResult — go to the resultCrude hazard ratio 4.23 95 % CI 3.73–4.80Authors' conclusion
Women diagnosed with PCOS at a younger age have the highest relative risk of developing diabetes, suggesting frequent glycemic status screening is required to detect diabetes at an early stage.
Study context
- Population
- Chinese women with PCOS, Hong Kong Diabetes Surveillance Databasematched cohort
- Participants
- 3,978 vs 39,780
- Exposure
- Women with PCOS vs age-matched controls without PCOS
- PCOSn = 3,978
- Controlsn = 39,780reference
- Outcome
- Progression to diabetes
Methodological detailsterritory-wide, matched 1:10 by age
- Territory-wide
- Matched 1:10 by age
Main finding
Incident diabetes · mean follow-up 6.28 ± 4.20 (PCOS) and 6.95 ± 4.33 (controls) years
Crude hazard ratio
4.23
95 % CI 3.73–4.80
P < 0.001
By group
PCOS
14.25/1000 person-years
Controls
3.45
PCOSvs Controls
crude HR 4.23 (95 % CI 3.73–4.80); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
- Risk decreased with increasing age but remained significantly higher in PCOS across all age groups
- Incidence in PCOS aged 20-29 highly comparable to healthy women aged ≥ 40
- More than half of incident diabetes in PCOS cohort was young-onset
Original publication
Young-onset diabetes in women with Polycystic Ovary Syndrome: A territory-wide retrospective analysis in Hong Kong. Diabetes Res Clin Pract. Published 23 March 2023. doi:10.
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