Increased mortality in polycystic ovary syndrome— a cohort study
Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.33 CI 1.12–1.59Authors' conclusion
The results suggest that women with PCOS have an increased overall mortality compared to women without PCOS. Effective strategies to reduce mortality risk in women with PCOS should be investigated.
Study context
- Population
- Women with polycystic ovary syndrome (PCOS) identified from Finnish nationwide health-care records, 1969–2019; follow-up from PCOS diagnosis1:3 matched cohort
- Participants
- 9,839 vs 28,238
- Exposure
- Women with PCOS vs matched controls without PCOS
- PCOSn = 9,839
- Controlsn = 28,238reference
- Outcome
- All-cause mortality
- Follow-up
- Median 12 years
Methodological detailsnationwide, 1:3 matched cases and controls, matched on age and residential area at birth
- Nationwide
- 1:3 matched cases and controls
- Matched on age and residential area at birth
Main finding
As reported in the abstract
Adjusted hazard ratio
1.33
CI 1.12–1.59
Events by group
PCOSvs Controls
aHR 1.33 (CI 1.12–1.59)
Observational data: associations, not effects.
Further findings
Mortality due to neoplasms (education-adjusted)
- Increased mortality due to neoplasms, education adjusted HR
- 1.39 [1.04-1.86]
Mortality due to diseases of the circulatory system (education-adjusted)
- Increased mortality due to diseases of the circulatory system, education adjusted HR
- 1.68 [1.14-2.50]
Mortality due to endocrine, nutritional and metabolic diseases
- Increased in the unadjusted model, HR
- 2.48 [1.03-5.98]
- Not increased in the education-adjusted model
Original publication
Increased mortality in polycystic ovary syndrome— a cohort study. Eur J Endocrinol. Published 29 May 2026. doi:10.
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