Evidence for actions of estrone distinct from those of estradiol
Authors' conclusion
Current evidence indicates that E1 is a biologically significant estrogen in its own right.
Study context
- Population
- Cell culture, animal models and clinical studies of E1 actions; postmenopausal women
- Comparison
- Estrone vs estradiol actions
- Outcome
- Distinct biological actions of E1
Methodological detailsSystematic search of PubMed, Ovid Medline, Embase, Web of Science and bibliographies
- Systematic search of PubMed, Ovid Medline, Embase, Web of Science and bibliographies
Pooled result
As reported in the abstract
Postmenopausal plasma E1 levels vs E2
4-fold higher
Postmenopausal E1 production through peripheral aromatization
8-fold higher
Original publication
Evidence for actions of estrone distinct from those of estradiol. J Clin Endocrinol Metab. Published 20 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →