Prevalence and accurate diagnosis of polycystic ovary syndrome in adolescents across world regions: a systematic review and meta-analysis
Authors' conclusion
This paramount global meta-analysis on adolescent PCOS diagnosis directly informed the 2023 International PCOS Guideline. Guideline criteria generated a global PCOS prevalence of 6.3%, compared with 9.8% on Rotterdam criteria (including PCOM). Excluding PCOM, which overlaps with normal pubertal transition, is expected to deter over-diagnosis. To avoid under-diagnosis, the Guideline recommends identifying those with either irregular cycles or hyperandrogenism as being "at risk"; this group should undergo longitudinal serial evaluations until adulthood.
Study context
- Population
- Unselected adolescent populations; studies 1990 to November 2023 from five world regions
- Participants
- 14,010 participants20 studies
- Comparison
- Original Rotterdam criteria vs International Evidence-based Guideline criteria (omitting polycystic ovarian morphology (PCOM)) for PCOS diagnosis
- Outcome
- Global prevalence of PCOS among adolescents
Methodological details24 articles reporting on 23 studies from five world regions included; 20 studies in meta-analysis
- 24 articles reporting on 23 studies from five world regions included; 20 studies in meta-analysis
Pooled result
As reported in the abstract
Global PCOS prevalence
Further pooled results
PCOS prevalence by WHO region (Guideline criteria)
- Western Pacific region (lowest)
- 2.9% (95% CI 2.0, 3.9)
- South-East Asia region (highest)
- 11.4% (95% CI 7.1, 15.7)
Original publication
Prevalence and accurate diagnosis of polycystic ovary syndrome in adolescents across world regions: a systematic review and meta-analysis. Eur J Endocrinol. Published 1 October 2024. doi:10.
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