Prevalence, Phenotypes, and Comorbidities of Polycystic Ovary Syndrome Among Indian Women
Authors' conclusion
In this cross-sectional study of reproductive-age women recruited across India, the prevalence of PCOS was high, with phenotype C being predominant. Most of these women had metabolic abnormalities. These findings are crucial for developing preventive and therapeutic strategies, potentially integrating PCOS management into national health programs.
Study context
- Population
- Indian women aged 18 to 40 years, recruited across 5 zones of the country, November 2018 to July 2022; mean (SD) age 29.5 (6.2) years9,824 recruited
- Participants
- 8,993 women
- Exposure
- Screen positive vs Screen negative vs Already diagnosed PCOS
- Screen positiven = 2,251
- Screen negativen = 6,546reference
- Already diagnosed PCOSn = 196
- Outcome
- Prevalence and phenotypes of PCOS among women of reproductive age and burden of comorbidities associated with PCOS
Methodological detailsnationwide, 5 zones of India, questionnaire screening
- Nationwide
- 5 zones of India
- Questionnaire screening
Main finding
As reported in the abstract
National prevalence of PCOS
- PCOS prevalence by NIH 1990 criteria
- 7.2% (95% CI 4.8%-10.8%)
- PCOS prevalence by Rotterdam 2003 criteria
- 19.6% (95% CI 12.7%-29.2%)
- PCOS prevalence by AE-PCOS criteria
- 13.6% (95% CI 8.4%-21.6%)
- Phenotype C, most common
- 501 [40.8%]
- Phenotype D
- 301 [24.6%]
- Pre-PCOS subgroup (partial phenotype only)
- 492
- Pre-PCOS: oligomenorrhea only
- 75
- Pre-PCOS: hyperandrogenism only
- 257
- Pre-PCOS: polycystic ovarian morphology only
- 160
Observational data: associations, not effects.
Further findings
Mean, years
| Outcome | Screen positive | Screen negative | P value |
|---|---|---|---|
| AgeScreen positive vs Screen negative · lower with Screen positive | 28.1 (SD 6.4) | 29.7 (SD 6.1) | P < 0.001 |
| Age at menarcheScreen positive vs Screen negative · higher with Screen positive | 13.2 (SD 1.3) | 13.1 (SD 1.2) | P < 0.001 |
Comorbidities among women with PCOS (n = 1224)
- Obesity
- 529 (43.2%)
- Dyslipidemia
- 1126 (91.9%)
- NAFLD
- 403 (32.9%)
- Metabolic syndrome
- 305 (24.9%)
- Impaired glucose tolerance
- 111 (9.1%)
- Diabetes
- 41 (3.3%)
- Hypertension
- 101 (8.3%)
Comorbidities in pre-PCOS subgroup (n = 492)
- Dyslipidemia
- 390 [79.3%]
- Metabolic syndrome
- 78 [15.9%]
- NAFLD
- 163 [33.1%]
- Impaired glucose tolerance
- 62 [12.6%]
- Diabetes
- 7 [1.4%]
- Hypertension
- 26 [5.3%]
Original publication
Prevalence, Phenotypes, and Comorbidities of Polycystic Ovary Syndrome Among Indian Women. JAMA Netw Open. Published 1 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →