Cardiometabolic Risk in First Degree Relatives of Women With Polycystic Ovary Syndrome (PCOS)
Authors' conclusion
FDRs of women with PCOS are at increased risk of cardiometabolic disorders.
Study context
- Population
- First degree relatives of women with PCOS; RCTs, observational studies, guidelines, systematic reviews and health technology assessments searched to 1st November 202334 unique studies
- Comparison
- First degree relatives (FDRs) of women with PCOS vs participants without a family history of PCOS
- Outcome
- CVD and cardiometabolic risk factors
Methodological detailsPRISMA guidelines adhered to, Most studies were judged as moderate risk of bias
- PRISMA guidelines adhered to
- Most studies were judged as moderate risk of bias
Pooled result
As reported in the abstract
Cardiometabolic risk factors
FDRs vs ControlsEstimate (95% CI)P value
I2 = 65%; six studies; 2059 participants
OR (metabolic syndrome) 2.50(1.40–4.45)
P = 0.002I2 = 0%; three studies; 302 participants
OR (hypertension) 2.05(1.08–3.92)
P = 0.03I2 = 9%; five studies; 778 participants
OR (diabetes) 2.46(1.31–4.62)
P = 0.005Original publication
Cardiometabolic Risk in First Degree Relatives of Women With Polycystic Ovary Syndrome (PCOS). Clin Endocrinol (Oxf). Published 24 June 2025. doi:10.
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