The Ontogeny of Distinct Reproductive Phenotypes in Girls at Risk for PCOS During the Postmenarchal Transition
Authors' conclusion
Both PCOS-d and OW-g had persistent HA during the early postmenarchal transition. However, ovulatory dysfunction and neuroendocrine abnormalities, elevated basal, and stimulated LH responses to GnRH analog were observed only in PCOS-d. These findings support the existence of distinct developmental trajectories leading to polycystic ovary syndrome, with early neuroendocrine dysregulation in PCOS-d and peripheral, likely adiposity-related, androgen excess in OW-g.
Study context
- Population
- Adolescent girls within .2 to 1.2 years of menarche
- Participants
- 15 / 12 / 17
- Exposure
- Polycystic ovary syndrome (PCOS-d) vs overweight/obesity (OW-g) vs LC
- PCOS-dn = 15
- OW-gn = 12
- LCn = 17reference
- Outcome
- Metabolic and reproductive phenotypes
Main finding
As reported in the abstract
- PCOS-d vs LC: P < 0.0001
- OW-g vs LC: P = 0.02
- PCOS-d vs LC: P = 0.04
- OW-g vs LC: P = 0.07
- PCOS-d vs OW-g: P = 0.02
- PCOS-d vs OW-g: LH area under the curve (AUC) P = .006
- PCOS-d vs OW-g: FSH AUC P = .01
- PCOS-d vs LC: χ2 P = .04
- PCOS-d vs OW-g: χ2 P = .05
Observational data: associations, not effects.
Original publication
The Ontogeny of Distinct Reproductive Phenotypes in Girls at Risk for PCOS During the Postmenarchal Transition. J Clin Endocrinol Metab. Published 20 June 2025. doi:10.
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