Lipids & metabolic liver disease
Risk Factors for Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients With Polycystic Ovary Syndrome in East Asia: A Review and Meta-Analysis
Authors' conclusion
MASLD is associated with obesity, IR, and hyperandrogenemia among PCOS women in East Asia. The abnormality of WHR, HOMA-IR, and testosterone suggested early screening of MASLD in this population.
Study context
- Population
- Women with polycystic ovary syndrome (PCOS) in East Asia; studies published before July 13, 202324 studies
- Comparison
- PCOS women with MASLD vs without MASLD
- Outcome
- Risk factors for MASLD in PCOS (pooled multivariate analysis)
Methodological detailsMOOSE statement
- MOOSE statement
Pooled result
As reported in the abstract
- Waist-to-hip ratio (WHR) substantially greater in PCOS women with MASLD
- P < .001
- Testosterone substantially greater in PCOS women with MASLD
- P = .034
- Homeostatic model assessment for insulin resistance (HOMA-IR) substantially greater in PCOS women with MASLD
- P = .02
Further pooled results
Univariate analysis
- Age, BMI, WHR, blood pressure, alanine transaminase, aspartate transaminase, fasting blood glucose, fasting insulin, HOMA-IR, 2-h postprandial blood glucose, 2-h insulin, HbA1c, LDL-C, TG, total cholesterol and testosterone notably higher in PCOS women with MASLD
- HDL-C markedly lower in PCOS women with MASLD
Original publication
Risk Factors for Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients With Polycystic Ovary Syndrome in East Asia: A Review and Meta-Analysis. Endocr Pract. Published 11 February 2025. doi:10.
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