Endocrine Responses to Triptorelin in Healthy Women, Women With Polycystic Ovary Syndrome, and Women With Hypothalamic Amenorrhea
Authors' conclusion
FSH response to triptorelin was attenuated in women with polycystic ovaries, both with and without ovarian stimulation, and was negatively related to AMH levels.
Study context
- Population
- Healthy women, women with polycystic ovary syndrome (PCOS) and women with hypothalamic amenorrhea (HA) without ovarian stimulation; women with or without polycystic ovaries undergoing oocyte donation cycles after ovarian stimulation
- Comparison
- Gonadotropin response to triptorelin in healthy women vs PCOS vs HA (Study 1); polycystic vs normal morphology ovaries in oocyte donation cycles (Study 2)
- Polycystic morphologyn = 60
- Normal morphologyn = 91reference
- Primary endpoint
- Change in serum gonadotropin levels after triptorelin
Methodological detailssingle-blinded
- Single-blinded
Primary result
As reported in the abstract
AUC of change in serum FSH (Study 1)
PCOS
127.2
median · IU.h/L
Healthy
253.8
median · IU.h/L
HA
326.7
median · IU.h/L
P = 0.0005
Further findings
| Outcome | Values | P value |
|---|---|---|
| Peak LH after triptorelin (Study 1) | Healthy mean 52.3 IU/L · PCOS mean 46.2 IU/L · HA mean 41.3 IU/L | |
| FSH 4 h after triptorelin (Study 2) · 4 hoursPolycystic morphology ovary vs Normal morphology ovaries · reduced with polycystic morphology | Polycystic morphology ovary 34.0 IU/L · Normal morphology ovaries 42.3 IU/L | P = 0.0003 |
Peak luteinizing hormone (LH) after triptorelin (Study 1)
- LH increase of similar amplitude in all women
Anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH) increase
- Serum AMH negatively associated with FSH increase after triptorelin, with and without ovarian stimulation
Original publication
Endocrine Responses to Triptorelin in Healthy Women, Women With Polycystic Ovary Syndrome, and Women With Hypothalamic Amenorrhea. J Clin Endocrinol Metab. Published 19 January 2023. doi:10.
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