The influence of body composition on the response to dynamic stimulation of the endocrine pituitary-testis axis
An erratum to this article was published (Int J Obes (Lond), Sep 2024 ↗)
Authors' conclusion
Dynamic sex hormone responses following pituitary-testis axis stimulation were less dependent on BMI, compared to the influence of BMI on basal hormone concentrations and could potentially assist clinical decision making in patients with obesity suspected of testosterone deficiency.
Study context
- Population
- Healthy men undergoing full biochemical assessment of the pituitary-testis axis with gonadotropin-releasing hormone (GnRH)- and hCG-stimulation tests; DXA-scan in a subset78 with DXA-scan · DXA-scan in a subset 78
- Participants
- 112 men
- Exposure
- Association of body mass index (BMI) and body composition with basal and dynamic (GnRH- and hCG-test) pituitary-testis axis responses
- Outcome
- Association of BMI with basal and stimulated LH and testosterone
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Higher BMI and basal serum luteinizing hormone (LH): BU
- −0.44 (−0.88--0.01), p = 0.04 (95% CI)
- BMI and GnRH-stimulated LH increase (not significant): BU
- −0.10 (−0.72-0.51), p = 0.74 (95% CI)
- High BMI and basal testosterone: BU
- −0.02 (−0.03--0.02), p < 0.001 (95% CI)
- High BMI and free testosterone: BU
- −15.0 (−19.9--10.0), p < 0.001 (95% CI)
- Lower testosterone, overweight vs normal weight
- 9%, p = 0.003
- Lower testosterone, obesity vs normal weight
- 24%, p < 0.001
- Lower free testosterone, overweight vs normal weight
- 25%, p = 0.006
- Lower free testosterone, obesity vs normal weight
- 50%, p < 0.001
- hCG-stimulated testosterone increase significantly less dependent on BMI than basal testosterone
- p = 0.04 for the interaction
Observational data: associations, not effects.
Original publication
The influence of body composition on the response to dynamic stimulation of the endocrine pituitary-testis axis. Int J Obes (Lond). Published 12 April 2024. doi:10.
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