The Influence of Gender-Affirming Hormone Therapy, With or Without Pubertal Suppression, on Sexual Function in Adults: A Pilot Study
Authors' conclusion
Our pilot study suggests that pubertal suppression with GnRHa was not associated with sexual function compared with GAHT alone.
Study context
- Population
- Transgender and gender diverse (TGD) adults (24 assigned female at birth, 34 assigned male at birth; mean age 22 years, range 18–25), 2 clinical sites
- Participants
- 58 adults
- Exposure
- Gonadotropin-releasing hormone agonists (GnRHa) + gender-affirming hormone therapy (GAHT) vs GAHT alone
- Outcome
- Sexual function and desire (Changes in Sexual Functioning Questionnaire 14; 5 domains)
Methodological detailspilot study, 2 clinical sites
- Pilot study
- 2 clinical sites
Main finding
As reported in the abstract
Sexual function
- No significant differences in sexual function between GAHT alone and GnRHa + GAHT
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Decreased sexual function, assigned male vs assigned female at birthAssigned male at birth vs Assigned female at birth · desire domain | P = 0.021 |
| Decreased sexual function, assigned male vs assigned female at birthAssigned male at birth vs Assigned female at birth · arousal domain | P = 0.040 |
| Decreased sexual function, assigned male vs assigned female at birthAssigned male at birth vs Assigned female at birth · orgasm domain | P < 0.001 |
Decreased sexual function, assigned male vs assigned female at birth
- Assigned male at birth participants had significantly higher rates of decreased sexual function across most domains
Original publication
The Influence of Gender-Affirming Hormone Therapy, With or Without Pubertal Suppression, on Sexual Function in Adults: A Pilot Study. Endocr Pract. Published 24 April 2026. doi:10.
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