Psychosocial Functioning in Transgender Youth after 2 Years of Hormones
An erratum to this article was published (N Engl J Med, 19 Oct 2023 ↗)
Authors' conclusion
In this 2-year study involving transgender and nonbinary youth, GAH improved appearance congruence and psychosocial functioning.
Study context
- Population
- Transgender and nonbinary youth aged 12 to 20 years (mean 16±1.9) initiating gender-affirming hormones (GAH) (testosterone or estradiol), United States; 60.3% transmasculine, 7.9% prior pubertal suppression
- Participants
- 315 participants
- Outcome
- Trajectories of appearance congruence, depression, anxiety, positive affect and life satisfaction
- Follow-up
- Baseline and 6, 12, 18 and 24 months after GAH initiation
Methodological detailsfour-site, observational, latent growth curve modeling
- Four-site
- Observational
- Latent growth curve modeling
Main finding
As reported in the abstract
Psychosocial functioning · 2 years
- Appearance congruence, positive affect and life satisfaction increased
- Depression and anxiety symptoms decreased
- Increases in appearance congruence associated with concurrent increases in positive affect and life satisfaction and decreases in depression and anxiety symptoms
Observational data: associations, not effects.
Safety
Participants
- Suicidal ideation (most common adverse event)
- 11 (3.5%)
- Death by suicide
- 2
Original publication
Psychosocial Functioning in Transgender Youth after 2 Years of Hormones. N Engl J Med. Published 19 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →