Early puberty suppression and gender-affirming hormones do not alter final height in transgender adolescents
Authors' conclusion
Early puberty suppression and GAH do not impact FH, supporting the safety of the treatment; however, trans adolescents achieve a FH in line with SRAB, rather than EG.
Study context
- Population
- Transgender adolescents at final height treated with early puberty suppression (Tanner stages 2 and 3) via gonadotropin-releasing hormone agonists (GnRHas) followed by gender-affirming hormones
- Participants
- 10 vs 22
- Exposure
- Final height vs target height and predicted adult height in trans boys and trans girls after early puberty suppression (ePS) and GAH
- Trans boysn = 10
- Trans girlsn = 22
- Outcome
- Impact of ePS and GAH on final height (FH)
Main finding
As reported in the abstract
Difference between FH and target height for sex registered at birth (most accurate predictor of FH)
| Group | Value | P |
|---|---|---|
| Trans boys | 1.57 ± 3.1 cm | P = .168 |
| Trans girls | −0.98 ± 4.17 cm | P = .319 |
Value
Trans boys1.57 ± 3.1 cm
Trans girls−0.98 ± 4.17 cm
P
Trans boysP = .168
Trans girlsP = .319
Observational data: associations, not effects.
Further findings
Total height gain since start of ePS
Achieved before start of GAH Trans boys 70%
Achieved before GAH Trans girls 61%
Age at start of PS
| Outcome | Trans boys | Trans girls |
|---|---|---|
| Difference between FH and PAH at start of PS for sex registered at birth | 2.62 ± 3.79 cm | −2.35 ± 5.2 cm |
| P | P = .056 | P = .051 |
Difference between final height (FH) and predicted adult height (PAH) at start of PS for sex registered at birth
- Nonsignificant in both trans boys and girls
Original publication
Early puberty suppression and gender-affirming hormones do not alter final height in transgender adolescents. Eur J Endocrinol. Published 13 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →