Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome
Authors' conclusion
Genetic risk factors for PCOS are associated with alterations in metabolic, growth, and developmental traits in childhood. Thus, PCOS may not simply be a condition that affects women of reproductive age but, rather, a possible manifestation of an underlying condition that affects both sexes starting in early life.
Study context
- Population
- Girls and boys in 4 pediatric cohorts: ALSPAC (UK), COPSAC (Denmark), Project Viva (USA), The HOLBÆK Study (Denmark)
- Participants
- 12,350 participants4 pediatric cohorts
- Comparison
- Higher vs lower polycystic ovary syndrome (PCOS) polygenic risk score
- Outcome
- Associations of PCOS PRS with childhood phenotypes
Methodological detailsmeta-analysis of 4 pediatric cohorts, polygenic risk score, fixed-effect meta-analysis, multicohort
- Meta-analysis of 4 pediatric cohorts
- Polygenic risk score
- Fixed-effect meta-analysis
- Multicohort
Pooled result
As reported in the abstract
- BMI in midchildhood, increase per 1 SD of polygenic risk score (PRS): 95% CI 0.03, 0.07; P = 3 × 10-5
- 0.05 kg/m²
- Obesity in early childhood, OR
- 1.34 (95% CI 1.13, 1.59; P = .0009)
- Higher BMI and obesity risk persisted through late adolescence
- P all ≤.03
- Age at pubarche, decrease per 1 SD of PRS: 95% CI −1.44, −0.26; P = .005
- 0.85-month
- Age at peak height velocity, decrease per 1 SD of PRS: 95% CI −0.94, −0.33; P = 4 × 10-5
- 0.64-month
Original publication
Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome. J Clin Endocrinol Metab. Published 10 September 2023. doi:10.
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