Gender-affirming treatment and mental health diagnoses in Danish transgender persons: a nationwide register-based cohort study
Authors' conclusion
The OR for mental health disorders was higher in transgender persons compared to controls and remained elevated throughout follow up, especially in transgender persons AMAB.
Study context
- Population
- Danish transgender persons with diagnosis code of "gender identity disorder", 2000–2021; median age 19 (assigned female at birth (AFAB)) and 23 (assigned male at birth (AMAB)) years3,812 transgender, 38,120 controls
- Participants
- 1,993 / 1,819 / 38,120
- Exposure
- Transgender persons vs age-matched controls
- AFABn = 1,993
- AMABn = 1,819
- Controlsn = 38,120reference
- Outcome
- Diagnosis codes of mental and behavioral disorders and/or prescription of psychopharmacological agents
- Follow-up
- Until June 2022
Methodological detailsage-matched controls, five controls of same sex and five of other sex at birth per transgender person
- Age-matched controls
- Five controls of same sex and five of other sex at birth per transgender person
Main finding
As reported in the abstract
Mental and behavioral disorders · before index date; 1, 5 and 8 years follow up
Odds ratio (95% CI)P value
AFABvs Control womenbefore index date
6.7(5.5–8.1)
AFABvs Control women1 year
9.9(8.4–11.7)
AFABvs Control women5 years
5.8(4.4–7.7)
AFABvs Control women8 years
3.4(2.1–7.5)
AMABvs Control menbefore index date
5.0(4.0–6.4)
all P < .001AMABvs Control men1 year
11.3(9.3–13.7)
all P < .001AMABvs Control men5 years
4.8(3.5–6.5)
all P < .001AMABvs Control men8 years
6.6(4.2–10.3)
all P < .001Observational data: associations, not effects.
Original publication
Gender-affirming treatment and mental health diagnoses in Danish transgender persons: a nationwide register-based cohort study. Eur J Endocrinol. Published 6 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →