Gender-affirming hormone therapy and its impact on myocardial mass and cardiac function: a prospective magnetic resonance cohort study on transgender men and women
Authors' conclusion
Myocardial mass increased, while NT-proBNP levels decreased significantly in AFAB after 6 months of GAHT. However, no significant changes in cardiac function were noted in AMAB and AFAB.
Study context
- Population
- Transgender individuals under gender-affirming hormone therapy (GAHT), Medical University of Vienna, 2019–2022
- Participants
- 20 vs 15
- Exposure
- Before vs after 6 months of GAHT in AFAB and AMAB transgender individuals
- AFABn = 20
- AMABn = 15
- Outcome
- Myocardial mass
- Follow-up
- 6 months
Methodological detailssingle-centre, cardiac MRI, magnetic resonance spectroscopy
- Single-centre
- Cardiac MRI
- Magnetic resonance spectroscopy
Main finding
As reported in the abstract
- AFAB: myocardial mass increased significantly from mean (±SD) 48 (±8) g/m² at baseline to 54 (±7) g/m²
- P = .011
- AMAB: nonsignificant decrease in myocardial mass
- 4 (±14) g/m²
Observational data: associations, not effects.
Further findings
Left ventricular ejection fraction (LVEF), stroke volume, cardiac output, peak filling rate · 6 months
- No significant changes in either group
Correlation of sex hormones and BMI with myocardial mass at follow-up
- Testosterone, AFAB
- r = −0.127, P = .679
- Testosterone, AMAB
- r = −0.127, P = .679
- Estradiol, AFAB
- r = −0.154, P = .616
- Estradiol, AMAB
- r = −0.154, P = .616
- BMI not related to myocardial mass
Brain natriuretic peptide levels in AFAB · 6 months
- Significantly reduced from median [IQR] 41 [26-57] to 19 [12-34] pg/mL
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Gender-affirming hormone therapy and its impact on myocardial mass and cardiac function: a prospective magnetic resonance cohort study on transgender men and women. Eur J Endocrinol. Published 28 March 2025. doi:10.
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