Single-cell profiling of the human endometrium in polycystic ovary syndrome
Study context
- Population
- Women with polycystic ovary syndrome (PCOS) characterized by overweight and obesity, hyperandrogenism and insulin resistance, and controls of similar age, weight and BMI; endometrium in proliferative phase27 biopsies
- Participants
- 5 / 12 / 7 / 3
- Comparison
- PCOS vs controls; PCOS after metformin or lifestyle intervention
- Controlsn = 5reference
- PCOS baselinen = 12
- Metforminn = 7
- Lifestyle interventionn = 3
- Outcome
- Endometrial cellular atlas
Methodological detailssingle-cell (single-nucleus) profiling
- Single-cell (single-nucleus) profiling
Main finding
As reported in the abstract
- Cell-type-specific disease signatures and variations in cellular composition and localization in PCOS
- Extensive recovery of disease-specific endometrial signatures after 16 weeks of metformin and lifestyle management
- Cell types linked to hyperandrogenism, insulin resistance and risk of endometrial and metabolic disease
- Potential therapeutic targets such as integrin inhibitors identified
Original publication
Single-cell profiling of the human endometrium in polycystic ovary syndrome. Nat Med. Published 20 March 2025. doi:10.
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