Sex Hormones, Sex Hormone‐Binding Globulin and Sleep Problems in Females With Polycystic Ovary Syndrome: A Systematic Review and Meta‐Analysis
Authors' conclusion
SHBG, rather than hyperandrogenism, may play a more important mechanistic role for OSA in PCOS, while other sleep disturbances exhibit a less severe SHBG profile. These findings enhance comprehension of underlying pathophysiology of sleep problems in PCOS. Further validation across PCOS populations is warranted.
Study context
- Population
- Females with polycystic ovary syndrome (PCOS); studies of serum sex hormones, sex hormone-binding globulin (SHBG) or hyperandrogenism with sleep disorders and/or disturbances; searches to 3 August 202424 studies included
- Comparison
- PCOS with obstructive sleep apnea (OSA) vs PCOS without OSA
- Outcome
- Prevalence of sleep problems and associations of serum sex hormones and SHBG with sleep problems
Methodological detailsrandom effects meta-analyses, 4487 studies screened; 9 suitable for meta-analyses
- Random effects meta-analyses
- 4487 studies screened; 9 suitable for meta-analyses
Pooled result
As reported in the abstract
Prevalence of sleep problems in PCOS
OSA
46.0%
Other sleep disturbances
56.0%
Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| SHBG levelsI2 = 0%; 179 participants; lower with OSA | −0.62 (−0.82 to −0.42) | P < 0.00001 | |
| −1−0.500.5Difference (linear scale) |
Total and free testosterone, DHEAS, androstenedione, oestradiol
- No differences between PCOS with vs without OSA
Sex hormones, SHBG or hyperandrogenism and sleep disturbances
- No significant associations observed
Original publication
Sex Hormones, Sex Hormone‐Binding Globulin and Sleep Problems in Females With Polycystic Ovary Syndrome: A Systematic Review and Meta‐Analysis. Clin Endocrinol (Oxf). Published 25 February 2025. doi:10.
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