Discriminatory Value of Steroid Hormones on Polycystic Ovary Syndrome and Clustering of Hyperandrogenism and Metabolic Factors
Authors' conclusion
Eleven-oxygenated androgens do not aid in the diagnosis of PCOS in women with obesity. Insulin resistance is the strongest PC in the PCOS group. There is no major dominant characteristic that defines obese non-PCOS women.
Study context
- Population
- Women with infertility and obesity
- Participants
- 132 vs 83
- Comparison
- Polycystic ovary syndrome (PCOS) vs ovulatory infertile controls, both with obesity
- PCOSn = 132
- Controlsn = 83reference
- Outcome
- Discrimination of PCOS by 11-oxygenated androgens vs total or free T and free androgen index (AUC)
Methodological detailscase-control, liquid chromatography tandem mass spectrometry, principal component analysis
- Case-control
- Liquid chromatography tandem mass spectrometry
- Principal component analysis
Performance
As reported in the abstract
AUC for discriminating PCOS
| Test or model | AUC |
|---|---|
| 11-ketotestosterone | 0.59 |
| Total T | 0.84 |
| Free T | 0.91 |
| Free androgen index | 0.85 |
AUC
11-ketotestosterone0.59
Total T0.84
Free T0.91
Free androgen index0.85
Further findings
| Outcome | PCOS | Controls | P value |
|---|---|---|---|
| 11-ketotestosteroneHigher with PCOS | 1.22 (bracketed range 0.84–1.65) nmol/L | 1.05 (bracketed range 0.78–1.35) | P = 0.04 |
| 11β-hydroxyandrostenedione | 4.30 (bracketed range 2.87–5.92) | 4.06 (bracketed range 3.22–5.73) | P = 0.44 |
Principal component analysis
- PCOS: 4 principal components (PCs) (insulin resistance status; blood pressure; obesity; androgen status), explained variance
- 72.1%
- Controls: 4 PCs, metabolic variables dispersed in components 2, 3 and 4, explained variance
- 68.7%
Original publication
Discriminatory Value of Steroid Hormones on Polycystic Ovary Syndrome and Clustering of Hyperandrogenism and Metabolic Factors. Endocr Pract. Published 18 January 2024. doi:10.
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