Thyroid Hormones Correlate to the Therapeutic Effect of Ovulation Induction in Infertile Women With Polycystic Ovary Syndrome
Authors' conclusion
Thyroid hormones significantly influence the efficacy of ovulation induction in infertile women with PCOS. Combined T3, T4, and TSH measurements enhance predictive accuracy for therapeutic responses, providing a foundation for personalized treatment strategies.
Study context
- Population
- Infertile women with polycystic ovary syndrome (PCOS) (Rotterdam criteria) undergoing ovulation induction with clomiphene citrate after Diane-35 pretreatment
- Participants
- 143 women
- Exposure
- Therapy-responsive vs nonresponsive women
- Responsiven = 97
- Nonresponsiven = 46reference
- Outcome
- Prediction of treatment response by combined T3, T4 and TSH (ROC)
Main finding
As reported in the abstract
Combined T3, T4 and thyroid-stimulating hormone (TSH) AUC
0.88
Sensitivity
76.09%
Specificity
86.60%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Baseline T3, T4 and TSH levelsSignificant differences | P < 0.001 |
Posttreatment thyroid hormone changes
- T3 and T4 increased and TSH decreased in the responsive group; no significant changes in the nonresponsive group
Endometrial thickness
- Positively correlated with T3 and T4, negatively with TSH
Original publication
Thyroid Hormones Correlate to the Therapeutic Effect of Ovulation Induction in Infertile Women With Polycystic Ovary Syndrome. Clin Endocrinol (Oxf). Published 9 September 2025. doi:10.
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