Risk assessment for aortic dissection in Turner syndrome: The role of the aortic growth rate
Authors' conclusion
Mean aortic growth in our TS population was increased compared to non-TS women and was not associated with currently known risk factors for AoD, suggesting that aortic growth rate itself could be a useful variable to stratify who is at risk for AoD.
Study context
- Population
- Adult women with Turner syndrome (TS); aortic growth study: women with >1 TTE after age 16 years70 with >1 TTE
- Participants
- 151 women
- Outcome
- Aortic growth rate at SoV and AA
Methodological detailsAortic diameters analysed by two experts
- Aortic diameters analysed by two experts
Main finding
As reported in the abstract
Mean aortic growth · interscan interval 4.7 years
Mean aortic growth at sinuses of Valsalva (SoV)
0.13 ± 0.59 mm/year
Mean aortic growth at ascending aorta (AA)
0.23 ± 0.82 mm/year
Observational data: associations, not effects.
Further findings
Association of risk factors and TS-related conditions with aortic growth
- Known risk factors for aortic dilatation and TS-related conditions were not associated with aortic growth
Aortic dissection
- Women with aortic dissection (AoD)
- 4/151
- Age at AoD
- 25±8 years
- Aortic growth, first woman with AoD (SoV and AA)
- 0.67 mm/year
- Aortic growth, second woman with AoD, SoV
- 11 mm/year
- Aortic growth, second woman with AoD, AA
- 4 mm/year
- Survived AoD (used TS cardiac-alert card)
- 1/4
Safety
- Preventive aortic replacement
- 5/151
- Died post-operatively
- 1
Original publication
Risk assessment for aortic dissection in Turner syndrome: The role of the aortic growth rate. Clin Endocrinol (Oxf). Published 12 January 2024. doi:10.
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