Sex steroid hormones and subclinical atherosclerosis progression in postmenopausal women
Authors' conclusion
Serum sex steroid hormones and SHBG relate differently to CIMT progression based on time since menopause. Estradiol, estrone, and SHBG levels show opposite associations with CIMT progression in early versus late postmenopause, highlighting the importance of HT timing in cardiovascular disease.
Study context
- Population
- Healthy postmenopausal women; nearly half received hormone therapy (HT)
- Participants
- 535 women
- Comparison
- Serum sex steroid hormones and sex hormone-binding globulin (SHBG) vs CIMT progression, by time since menopause
- Primary endpoint
- CIMT progression in relation to serum estradiol, estrone, testosterone and SHBG, with time since menopause as interaction term
Methodological detailspost-trial analysis
- Post-trial analysis
Primary result
As reported in the abstract
Association of hormones/SHBG with CIMT progression by time since menopause
- Associations of estradiol, estrone and SHBG with CIMT progression differed by time since menopause
- interaction P < .01
- Early postmenopause: CIMT progression significantly inversely associated with SHBG
- P = .024
- Late postmenopause: CIMT progression positively associated with estradiol
- P = .005
- Late postmenopause: CIMT progression positively associated with estrone
- P < .001
- Late postmenopause: CIMT progression positively associated with SHBG
- P = .037
Further findings
Baseline characteristics
- Late postmenopausal women were older with higher baseline CIMT
Original publication
Sex steroid hormones and subclinical atherosclerosis progression in postmenopausal women. Eur J Endocrinol. Published 21 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →