Serum Estradiol Concentrations With Estradiol 0.06% Gel in Transgender and Gender‐Diverse Adults
Authors' conclusion
Estradiol 0.06% gel achieves target serum estradiol concentrations in a significant proportion of transgender and gender-diverse adults. This represents an alternative estradiol formulation for individuals desiring estradiol therapy for gender affirmation.
Study context
- Population
- Transgender and gender-diverse adults treated with estradiol 0.06% gel at endocrine clinics in Melbourne, Australia
- Participants
- 81 participants
- Outcome
- Estradiol 0.06% gel dose, serum estradiol concentration and proportion achieving target serum estradiol concentrations of consensus guidelines
Methodological detailsaudit, endocrine clinics in Melbourne, Australia
- Audit
- Endocrine clinics in Melbourne, Australia
Main finding
As reported in the abstract
Serum estradiol concentration
| Group | Value | Median daily gel dose | Within target range (250-600 pmol/L) | Below range | Above range |
|---|---|---|---|---|---|
| Estradiol 0.06% gel | median 396 (range not specified 233–681) pmol/L | 1.5 mg (1.5-2.25) | 46% | 27% | 27% |
Estradiol 0.06% gel
Valuemedian 396 (range not specified 233–681) pmol/L
Median daily gel dose1.5 mg (1.5-2.25)
Within target range (250-600 pmol/L)46%
Below range27%
Above range27%
- Correlation between gel dose and serum estradiol (weak positive), r
- 0.23, p = 0.04
Observational data: associations, not effects.
Original publication
Serum Estradiol Concentrations With Estradiol 0.06% Gel in Transgender and Gender‐Diverse Adults. Clin Endocrinol (Oxf). Published 14 February 2025. doi:10.
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