Serum Hormone Concentrations in Transgender Youth Receiving Estradiol
Authors' conclusion
Oral, transdermal, and subcutaneous administrations of estrogen all lead to increased serum estradiol levels and are effective for use in gender-affirming care for youth. Patients on transdermal estrogen tended to have lower serum estradiol levels but also had more suppression of serum testosterone levels.
Study context
- Population
- Gender-diverse youth who initiated estradiol at an adolescent gender clinic, 2010–2019; mean (SD) age 17.2 (1.6) years
- Participants
- 118 participants
- Exposure
- Estradiol routes: oral vs transdermal vs subcutaneous
- Outcome
- Serum estradiol levels by estradiol route; suppression of serum testosterone
Methodological detailssingle adolescent gender clinic
- Single adolescent gender clinic
Main finding
As reported in the abstract
Serum estradiol
Observational data: associations, not effects.
Further findings
Route distribution
Testosterone in patients receiving spironolactone
- Transdermal estradiol associated with lower testosterone than oral or subcutaneous estradiol
Original publication
Serum Hormone Concentrations in Transgender Youth Receiving Estradiol. Endocr Pract. Published 27 November 2023. doi:10.
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