Endogenous Sex Steroid Hormones, Sex Hormone-Binding Globulin, and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
Pooled result · All-cause mortality by TT level, menResult — go to the resultHazard ratio 0.89 95% CI 0.83–0.97Authors' conclusion
This meta-analysis reveals a dose-response link between endogenous sex steroid hormones and mortality, highlighting the need for sex-specific studies on hormone modulation's impact on mortality and longevity.
Study context
- Population
- General population, population-based cohort studies; men and women analysed separately53 publications
- Participants
- 359,047 participants
- Comparison
- Top vs bottom tertile of endogenous sex hormones and sex hormone-binding globulin (SHBG)
- Outcome
- All-cause and cause-specific mortality
Methodological detailsrandom effects model, top vs bottom tertile, ROBINS-E risk of bias, GRADE certainty of evidence
- Random effects model
- Top vs bottom tertile
- ROBINS-E risk of bias
- GRADE certainty of evidence
Pooled result
All-cause mortality by TT level, men
Hazard ratio
0.89
95% CI 0.83–0.97
Topvs bottom tertile of endogenous sex hormones and SHBG
HR 0.89 (95% CI 0.83–0.97)
As reported in the abstract
Further pooled results
All-cause mortality by SHBG level, women
| HR (CI) | ||
|---|---|---|
| Higher SHBGWomen; n = 3 | 1.25 (1.13–1.39) | |
| 0.512Hazard ratio (log scale) |
All-cause mortality by DHEA sulfate (DHEAS) level, men
| HR (CI) | ||
|---|---|---|
| Higher DHEASMen; n = 6 | 0.72 (0.57–0.91) | |
| 0.512Hazard ratio (log scale) |
All-cause mortality by SHBG level, women
- No association between SHBG and all-cause mortality in men
All-cause mortality by DHEAS level, men
- No association between DHEAS and all-cause mortality in women
Original publication
Endogenous Sex Steroid Hormones, Sex Hormone-Binding Globulin, and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies. J Clin Endocrinol Metab. Published 7 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →