Reproductive endocrinology

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clin Endocrinol (Oxf)Published Systematic review

Authors' conclusion

While a healthy lifestyle is proven to prevent chronic diseases and improve QoL in postmenopausal women, there is limited evidence specific to women with POI. Targeted studies are needed to determine the most effective interventions for addressing their heightened risks and unmet needs.

Study context

Population
Women with premature ovarian insufficiency (POI) (loss of ovarian function before age 40); RCTs and quasi-experimental trials, PubMed and Medline, January 2014 to February 20243 studies
Comparison
Lifestyle interventions in women with POI
Outcome
Role of lifestyle interventions in POI
Methodological details2 studies in cancer survivors, 1 in Turner syndrome, 890 citations; 1 study met inclusion criteria, 2 added from other guideline chapter searches, Risk of bias assessed with Joanna Briggs Institute critical appraisal tool
  • 2 studies in cancer survivors, 1 in Turner syndrome
  • 890 citations; 1 study met inclusion criteria, 2 added from other guideline chapter searches
  • Risk of bias assessed with Joanna Briggs Institute critical appraisal tool

Pooled result

As reported in the abstract

  • Limited evidence suggests lifestyle interventions, particularly physical activity, improve cardiovascular health and BMD in women with POI
  • Effect of dietary supplementation was mixed

Original publication

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency. Clin Endocrinol (Oxf). Published 24 February 2025. doi:10.1111/cen.15218

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