Menopause‐Related Changes in Body Composition Are Associated With Subsequent Bone Mineral Density and Fractures: Study of Women's Health Across the Nation
Authors' conclusion
MT-related lean mass loss and fat mass gain were associated differentially with BMD; both were independently related to more fractures.
Study context
- Population
- Women from the Study of Women's Health Across the Nation (SWAN) not taking bone-beneficial or bone-detrimental medications before or during the menopause transition (2 years before to 2 years after the final menstrual period)
- Participants
- 539 women
- Exposure
- Per SD increment in % lean mass loss and % fat mass gain during the menopause transition (mutually adjusted)
- Outcome
- FN and LS BMD at the end of the menopause transition; fracture after the menopause transition
Methodological detailsmultivariable linear regression, Cox proportional hazards regression
- Multivariable linear regression
- Cox proportional hazards regression
Main finding
As reported in the abstract
Each SD (6.9%) increment in lean mass loss: lower femoral neck (FN) bone mineral density (BMD), p < 0.0001
0.010 g/cm²
Each SD (19.9%) increment in fat mass gain: greater FN (p = 0.009) and lumbar spine (LS) (p = 0.03) BMD
0.026 g/cm²
Each SD increment in lean mass loss: greater fracture hazard after the menopause transition (MT), p = 0.001
63%
Each SD increment in fat mass gain: greater fracture hazard after the MT, p = 0.05
28%
Observational data: associations, not effects.
Original publication
Menopause‐Related Changes in Body Composition Are Associated With Subsequent Bone Mineral Density and Fractures: Study of Women's Health Across the Nation. J Bone Miner Res. Published 17 January 2023. doi:10.
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