Trajectories of areal bone mineral density significantly differ by patterning of femoral neck area and bone mineral content across the menopausal transition
Authors' conclusion
Consideration of BMC and bone area changes across the lifecourse represents a novel approach to understand the overall bone health, and may elucidate an at-risk group not identified on aBMD alone.
Study context
- Population
- Women of the Michigan Bone Health and Metabolism Study (aged 24–50 at recruitment in 1992, followed near annually through 2010) with an observed non-surgical final menstrual period (FMP), a DXA scan 10 yr before FMP and ≥1 post-FMP DXA; FN DXA
- Participants
- 97 women
- Exposure
- Highest Bone Area vs Fastest BMC Decline
- Outcome
- Trajectory groups of FN bone area and BMC across the menopausal transition
Methodological detailsgroup-based trajectory modeling
- Group-based trajectory modeling
Main finding
As reported in the abstract
Trajectory groups identified for both bone area and BMC
3
Women in "Highest Bone Area" group (initial steep increases in bone area, continued increase around FMP)
27.8%
Women in "Fastest BMC Decline" group (substantial BMC decline after FMP)
26%
Areal BMD (aBMD) decline in women in both "Highest Bone Area" and "Fastest BMC Decline" groups: greatest aBMD decline, despite higher baseline aBMD (mean decrease, SD 8.1%)
12.8%
Observational data: associations, not effects.
Original publication
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