Classic and 11-oxygenated androgens in serum and saliva across adulthood: a cross-sectional study analyzing the impact of age, body mass index, and diurnal and menstrual cycle variation
Authors' conclusion
Classic androgens decrease while active 11-oxygenated androgens increase with increasing BMI, pointing toward the importance of adipose tissue mass for the activation of 11-oxygenated androgens. Classic but not 11-oxygenated androgens decline with age.
Study context
- Population
- Healthy adult volunteers across the age and body mass index (BMI) range; morning serum, saliva sub-group, diurnal and menstrual cycle saliva profiles
- Participants
- 290 healthy volunteers
- Exposure
- Men vs Women
- Menn = 125
- Womenn = 165
- Outcome
- Serum androgens vs age-adjusted BMI (%change per kg/m²)
Methodological detailsSteroids quantified by liquid chromatography-tandem mass spectrometry
- Steroids quantified by liquid chromatography-tandem mass spectrometry
Main finding
As reported in the abstract
5α-dihydrotestosterone %change per kg/m², men
−5.54%
95% CI −8.10 to −2.98
5α-dihydrotestosterone %change per kg/m², women
−1.62%
95% CI −3.16 to −0.08
11-ketotestosterone %change per kg/m², men
3.05%
95% CI 0.08–6.03
11-ketotestosterone %change per kg/m², women
1.68%
95% CI −0.44 to 3.79
Observational data: associations, not effects.
Further findings
Androgens vs age
- Classic androgens decreased with age in men and women; 11-oxygenated androgens did not
Diurnal variation of salivary androgens
- Diurnal pattern in men and in women's follicular phase; in luteal phase only 11-oxygenated androgens varied diurnally
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →