Semaglutide delays 4‐hour gastric emptying in women with polycystic ovary syndrome and obesity
Authors' conclusion
Semaglutide markedly delayed 4-hour GE in women with PCOS and obesity.
Study context
- Population
- Obese women with polycystic ovary syndrome (PCOS); mean [range] age 35 [32.3–40.8] years, BMI 37 [30.7–39.8] kg/m²
- Participants
- 20 women
- Comparison
- Once-weekly SC semaglutide 1.0 mg vs placebo for 12 weeks
- Primary endpoint
- Late digestive period of gastric emptying after a standardized solid test meal, by technetium scintigraphy over 4 hours
- Follow-up
- Baseline and Week 13
Methodological detailssingle-blind, placebo-controlled
- Single-blind
- Placebo-controlled
Primary result
As reported in the abstract
Gastric retention of solid meal · 4 hours after ingestion
Semaglutide
37%
P = 0.002
Further findings
Gastric half-emptying time · significantly longer with semaglutide
P < 0.001
Increase in estimated retention of gastric contents with semaglutide, baseline to study end · 1, 2, 3 and 4 hours after ingestion
- Increase at 1 hour
- 3.5%
- Increase at 2 hours
- 25.5%
- Increase at 3 hours
- 38.0%
- Increase at 4 hours
- 30.0%
Original publication
Semaglutide delays 4‐hour gastric emptying in women with polycystic ovary syndrome and obesity. Diabetes Obes Metab. Published 3 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →