Evaluation of coronary microvascular dysfunction and risk factors in children and youth with Turner syndrome by magnetic resonance myocardial perfusion imaging
Authors' conclusion
Myocardial microvascular dysfunction can occur in children and youth patients with TS. Age and overweight/obesity were the independent risk factors of microvascular dysfunction, which imply the importance of lowering BMI for the prevention of coronary heart disease in young TS population.
Study context
- Population
- Children and youth with turner syndrome (TS) and age- and gender-matched controls
- Participants
- 67 vs 32
- Exposure
- TS vs matched controls
- TSn = 67
- Controlsn = 32reference
- Outcome
- Myocardial microvascular function by first-pass cardiovascular MRI perfusion imaging, and risk factors for microvascular dysfunction
Methodological detailsage- and gender-matched controls
- Age- and gender-matched controls
Main finding
As reported in the abstract
Age as independent impact factor of microvascular dysfunction (multivariable linear regression): β (95% CI), p
−0.107
−0.201 to −0.013p = .026
Overweight/obese as independent impact factor of microvascular dysfunction (multivariable linear regression): β (CI), p
−1.155
−2.134 to −0.176p = .021
Observational data: associations, not effects.
Further findings
Subgroups: older TS patients; overweight/obese TS patients
- Upslopecor of older TS patients decreased more significantly vs normal controls
- Upslopecor and maximum signal intensity (MaxSI) lower in overweight/obese TS patients than in TS patients with normal body mass index (BMI) and controls
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →