Cerebrovascular Function in Women With Polycystic Ovary Syndrome: A Pilot Multi‐Parameter Magnetic Resonance Imaging Study
Main finding · Cerebral blood flow (CBF), PCOS vs HCResult — go to the resultRegional reduction in transverse temporal gyrus −29.05 mL/100 g/minAuthors' conclusion
We observed regional reduction in cerebral blood flow and regional increase in cerebrovascular reactivity in women with PCOS compared to healthy controls. However, due to the limited statistical power and unclear menstrual timing in this pilot study, these results require further replication.
Study context
- Population
- Women with polycystic ovary syndrome (PCOS) and healthy volunteers; 3T magnetic resonance imaging (MRI) of cerebrovascular perfusion, pulsatility, reactivity and metabolism
- Participants
- 15 vs 12
- Comparison
- Women with PCOS vs healthy controls
- PCOSn = 15
- Healthy controls (HC)n = 12reference
- Outcome
- Cerebral blood flow (CBF), PCOS vs HC
Methodological detailspilot
- Pilot
Main finding
As reported in the abstract
Regional reduction in transverse temporal gyrus
−29.05 mL/100 g/min
P = 0.03
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Breath-hold induced cerebrovascular reactivity (CVR)PCOS vs HC · PCOS status not associated with overall CVR; χ2(1) = 0.78 | P = 0.38 |
| Breath-hold induced cerebrovascular reactivity (CVR)PCOS vs HC · χ2(84) = 154.25 | P < 0.001 |
- Breath-hold induced cerebrovascular reactivity (CVR) — Parahippocampus, % signal change (± SE 0.27)
- 1.37
- Breath-hold induced cerebrovascular reactivity (CVR) — Pericalcarine cortex, % signal change (± SE 0.26)
- 1.04
- Breath-hold induced cerebrovascular reactivity (CVR): CVR: PCOS n = 15, HC n = 10
Testosterone and Homeostatic Model Assessment for Insulin Resistance (HOMA2-IR)
- Neither testosterone nor HOMA2-IR was associated with any outcome measure
Original publication
Cerebrovascular Function in Women With Polycystic Ovary Syndrome: A Pilot Multi‐Parameter Magnetic Resonance Imaging Study. Clin Endocrinol (Oxf). Published 1 December 2025. doi:10.
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