Resting Cerebrovascular Haemodynamics and Dynamic Assessment of Cerebrovascular Function in Polycystic Ovary Syndrome
Authors' conclusion
Cerebrovascular function is largely preserved in women with PCOS, although elevated arterial pulsatility and impaired vasodilatory response to carbon dioxide may indicate early endothelial dysfunction in the cerebral vasculature. Larger studies are needed to confirm this in view of our limited study power.
Study context
- Population
- Women with Polycystic Ovary Syndrome (PCOS) and healthy controls
- Participants
- 15 vs 16
- Comparison
- Women with PCOS vs healthy controls
- PCOSn = 15
- Controlsn = 16reference
- Outcome
- Resting global cerebral blood flow (3T MRI)
Main finding
As reported in the abstract
P = 0.25
Observational data: associations, not effects.
Further findings
| Outcome | PCOS | Controls | P value |
|---|---|---|---|
| Relative PCAPI during NVCElevated with PCOS | 12.0% ± 5.6% | 7.0% ± 3.8% | P = 0.04 |
| ICA vasodilation during CVRCO2Impaired with PCOS | −0.10 ± 0.22 mm | 0.18 ± 0.24 mm | P < 0.01 |
- Resting MCAv, PCAv, MCAPI and PCAPI
- all p > 0.05
- Neurovascular coupling (NVC)
- P = 0.45
- ICA cerebrovascular reactivity to CO2 (CVRCO2)
- P = 0.20
Resting MCAv, PCAv, MCAPI and PCAPI
- Similar between groups
Neurovascular coupling (NVC)
- Similar between groups
ICA cerebrovascular reactivity to CO2 (CVRCO2)
- Similar between groups
Dynamic cerebral autoregulation directional sensitivity
- Similar between groups
Original publication
Resting Cerebrovascular Haemodynamics and Dynamic Assessment of Cerebrovascular Function in Polycystic Ovary Syndrome. Clin Endocrinol (Oxf). Published 25 November 2025. doi:10.
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