The effect of nutraceutical interventions on reproductive health outcomes in women with polycystic ovary syndrome: A systematic review and meta‐analysis
Authors' conclusion
Nutraceutical interventions targeting metabolic and hormonal regulation may complement lifestyle therapy in women with PCOS. Interpretation is limited by study heterogeneity and variable methodological quality. No external funding was received.
Study context
- Population
- Women with polycystic ovary syndrome (PCOS); studies January 2013–December 202478 studies
- Comparison
- Nutraceutical interventions in PCOS
- Outcome
- Metabolic and hormonal outcomes
Methodological detailsPRISMA 2020, GRADE
- PRISMA 2020
- GRADE
Pooled result
As reported in the abstract
Fasting insulin reduced, MD
−2.14 μIU/mL
95% CI −3.12 to −1.16
LH reduced, MD
−1.34 mIU/mL
95% CI −2.10 to −0.58
SHBG increased, MD
+3.72 nmol/L
95% CI 1.35 to 6.09
Further pooled results
Ovarian follicle count and menstrual bleeding
- Results were inconsistent
Original publication
The effect of nutraceutical interventions on reproductive health outcomes in women with polycystic ovary syndrome: A systematic review and meta‐analysis. Diabetes Obes Metab. Published 24 November 2025. doi:10.
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