Pancreatic Body and Hepatic Fat Content Predict Impaired Glucose Regulation in Women With Polycystic Ovary Syndrome
Authors' conclusion
Pancreatic body and hepatic fat content predict IGR and synergistically regulate glucose metabolism in PCOS.
Study context
- Population
- Women with polycystic ovary syndrome (PCOS) undergoing OGTT
- Participants
- 160 women
- Exposure
- Pancreatic and hepatic fat content vs glucose metabolism
- Outcome
- Impaired glucose regulation (IGR)
Main finding
As reported in the abstract
Elevated pancreatic body fat, independently associated with higher impaired glucose regulation (IGR) risk: OR (95% CI 1.01-4.85), P = .047
2.21
Elevated hepatic average fat, independently associated with higher IGR risk: OR (95% CI 1.13-7.51), P = .026
2.92
Elevated levels of both pancreatic body fat and hepatic average fat, IGR risk after multiple confounding adjustments: OR (95% CI 1.63-18.47), P = .006
5.49
Observational data: associations, not effects.
Further findings
Pancreatic interlobular fat volume, pancreatic body fat and hepatic fat: diabetes vs normal glucose tolerance
- Significantly higher in PCOS patients with diabetes than with normal glucose tolerance (P < .05)
Hepatic average fat to pancreatic body fat ratio and IGR risk
- Lost significant association with IGR risk after multivariable adjustment (P = .705)
Prediction of IGR: pancreatic body fat and hepatic average fat plus traditional risk factors (age, BMI, WHR, serum TG, free androgen index)
- Trend toward improved predictive performance; highest AUC
- 0.789
Original publication
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