Reconsidering the olfactory and brain structures in Kallmann's syndrome: New findings in the analysis of volumetry
Authors' conclusion
Olfactory assessment and MRI proved to be important auxiliary tools for the diagnosis and management of patients with KS. New studies are needed to confirm the decrease in brainstem volume found by the Freesurfer software in patients with KS. Further studies are needed to confirm the decrease in brainstem volume found by the Freesurfer software in patients with KS.
Study context
- Population
- Adults with Kallmann's syndrome evaluated by olfactory Sniffin' Stick test and brain magnetic resonance imaging (MRI) with Freesurfer volumetry
- Participants
- 17 vs 34
- Exposure
- Kallmann's syndrome (KS) patients vs healthy controls
- KSn = 17
- Controlsn = 34reference
- Outcome
- Olfactory function and MRI findings in KS
Methodological detailscase-control comparison, matched for age and sex
- Case-control comparison
- Matched for age and sex
Main finding
As reported in the abstract
- Changes in olfactory groove on MRI
- 16 patients
- Olfactory bulb-tract complex altered
- all patients
- Symmetrical structural changes
- 52%
- Normal pituitary gland
- 29%
Observational data: associations, not effects.
Further findings
Anosmia by symmetry of olfactory structural changes
P = 0.0294
- Brainstem volume by anterior olfactory sulcus status · Aplastic anterior olfactory sulcus vs Hypoplasia · lower brainstem volume with aplasia
- P = 0.0333
Original publication
Reconsidering the olfactory and brain structures in Kallmann's syndrome: New findings in the analysis of volumetry. Clin Endocrinol (Oxf). Published 25 December 2022. doi:10.
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