Associations of body composition measures with circulating insulin-like growth factor-I, testosterone, and sex hormone-binding globulin concentrations in 16,000 men
Authors' conclusion
Our results show that common adiposity and most MRI measures of adiposity relate similarly to serum hormone concentrations; however, associations with ectopic fat (particularly MFI) and lean tissue were different.
Study context
- Population
- Men in the UK Biobank study with body composition data (visceral, subcutaneous and liver fat, muscle fat infiltration (MFI), lean tissue, common adiposity measures) and serum IGF-1, total testosterone, sex hormone-binding globulin (SHBG) and calculated free testosteroneup to
- Participants
- 16,237 men
- Exposure
- Categories of magnetic resonance imaging (MRI) body composition and common adiposity measures
- Outcome
- Geometric mean hormone (IGF-1, total and free testosterone) and SHBG concentrations across categories of each body composition measure
Methodological detailsmultivariable-adjusted linear regression
- Multivariable-adjusted linear regression
Main finding
As reported in the abstract
Associations of body composition with IGF-1, testosterone and SHBG
Correlation of common adiposity measures with MRI central and total adiposity
r = 0.76-0.91
Correlation of common adiposity measures with ectopic fat (liver fat and MFI)
r = 0.43-0.54
All body composition measures inversely associated with total testosterone and SHBG; relative geometric mean difference Q5 vs Q1
20-30%
Observational data: associations, not effects.
Original publication
Associations of body composition measures with circulating insulin-like growth factor-I, testosterone, and sex hormone-binding globulin concentrations in 16,000 men. Int J Obes (Lond). Published 21 October 2024. doi:10.
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