Effect of Endogenous Hormone Levels on Basal Metabolic Rate in Men With Obesity
Authors' conclusion
In men with obesity, endogenous DHEAS is positively associated with BMR. Testosterone, TSH, fT4 and IGF-1 were not associated with BMR in men with obesity. Since we examined the specific population of men with obesity and only examined endogenous hormone levels, no extrapolation of results to other populations or the overall population can be made.
Study context
- Population
- Men referred to a centre for a metabolic work-up; median age 47 (18–78) years; 90.9% with obesity (BMI ≥ 30 kg/m²)
- Participants
- 457 men
- Exposure
- Low, normal and/or high levels of testosterone, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS), IGF-1, thyroid-stimulating hormone (TSH) and FT4, compared for basal metabolic rate (BMR)
- Outcome
- Association between hormone levels and BMR (linear regression, controlled for FFM, FM and age)
Main finding
As reported in the abstract
Association of endogenous hormone levels with BMR in men with obesity
- DHEAS positively associated with BMR (men with obesity and normal DHEAS levels); BMR [kcal/d] = 513.402 + 18.940 × fat-free mass (FFM) [kg] + 9.507 × fat mass (FM) [kg] - 3.362 × age [years] + 0.307 × DHEAS [µg/dL]; adjusted R² = 0.72
- p < 0.01
Observational data: associations, not effects.
Original publication
Effect of Endogenous Hormone Levels on Basal Metabolic Rate in Men With Obesity. Clin Endocrinol (Oxf). Published 27 October 2024. doi:10.
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